Читать книгу Super Human: The Bulletproof Plan to Age Backward and Maybe Even Live Forever онлайн

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The common diabetes drug metformin is also believed to kill senescent cells. In studies, metformin has been shown to alleviate a range of age-related disorders in animals and humans, including metabolic dysfunction, cardiovascular disease, cancer development, and cognitive dysfunction.⁸ In elderly humans, it has been shown to increase life-span by an additional five years.⁹ Studies on mice show that these effects stem from reduced cellular senescence and fewer free radicals.¹⁰

Another exciting zombie killer is rapamycin. This drug inhibits a growth pathway called mammalian target of rapamycin (mTOR), which is responsible for regulating critical cellular functions such as cell growth, cell death, cell proliferation, and autophagy. Inhibiting mTOR appears to prevent the growth of senescent cells. In mice, rapamycin increases life-span, improves immune response, delays tissue loss, alleviates frailty with age, and decreases risk of heart failure, cancer, and cognitive impairment.¹¹ Not bad. Some doctors have quietly been using it as an anti-senescence drug since 2015.