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In the previous chapter we discussed Satchin Panda’s research on longevity and circadian rhythms. As part of my research for this book I went to his lab and had a great time with his PhD students looking at how the combination of food, light, and too little sleep affected rats. They walked me through new research showing that eating late at night dramatically reduced the quality of the rats’ sleep and that poor sleep impacted the rats’ ability to control blood sugar by up to 50 percent. That’s huge! In fact, it’s more than what most medications can do.

In rats and humans, the pancreas is responsible for making insulin. Satchin has studied insulin-producing cells in the pancreas and found that they, too, have their own circadian rhythm. At night when melatonin, a hormone that helps regulate wake and sleep cycles, is released, insulin-producing cells shut down, too. So if you eat something sugary late at night, your body’s insulin response is not as effective as usual. So that late-night piece of cake leads to a blood sugar spike and then a crash that triggers the release of adrenaline … which keeps you awake at three A.M.